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Sugar Sugar Rune (シュガシュガルーン, Shuga Shuga Rūn?) or Sugar² Rune is a manga by Moyoco Anno and an anime TV series based upon it. The anime series' time slot was replaced by Demashita! Powerpuff Girls Z in mid-2006.
The story is about two best friends, Chocolat Meilleure and Vanilla Mieux, who are young witches from the Magical World.