Recurring themes in his manga are crime, sexual deviations, and the human mind.
Hideo Yamamoto received the "Tetsuya Chiba Award", given to promising young manga creators in 1988. After resigning from the post of assistant of a popular seinen manga artist, Kenshi Hirokane, he made his professional debut by drawing "SHEEP" (written by Masahiko Takasho) for Weekly Young Sunday in 1989.
Before creating Homunculus, Hideo Yamamoto actually lived as a homeless person for sometime in order to be able to credibly include the theme of homelessness in his work. Yamamoto is also interested in martial arts.
- SHEEP (1989)
- Okama Hakusho (Transvestite Report, 1989–1991) - made into an OVA in 1991.
- Nozokiya (Voyeur, 1992)
- 1 (Ichi) (1993)
- Enjou Kousai Bokumetsu Undou (Compensated Dating Eradication Movement, drawn by Koshiba Tetsuya)
- Shin Nozokiya (Voyeur Inc., 1993–1997)
- Koroshiya Ichi (Ichi the Killer, 1998–2001) - adapted into a movie by Takashi Miike in 2001. Also, a prequel OVA, explaining the causes of Ichi's misery, was made.
- Homunculus (2003–2011 )
- Yume Onna (2013)